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(D) Hepatic triglyceride (TG) content

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When oxygen is available, pyruvate can be oxidized to acetyl CoA, with a reduction of NAD +

But not everyone follows a textbook path

For individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) , intestinal permeability plays a central role in driving the debilitating symptom of post-exertional malaise (PEM) and chronic neuroinflammation